Panthers vs Saints Odds: Who Is Favored To Win?
Here are the early odds for the Panthers vs Saints Week 10 matchup. Based on odds from DraftKings, the Panthers have a 66.4% chance of winning the game. A lot can happen in the first ten weeks of the NFL, so expect the odds to shift before kickoff.
| 🏈 Point Spread | Saints +4.5, Panthers -4.5 |
| 📈 Moneyline | Saints +164, Panthers -198 |
| 📊 Total | O/U 43.5 (-110) |
| ✅ Last Verified: | August 25, 2025 |
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Panthers vs Saints Spread: What It Means
The 4.5‑point spread shows that oddsmakers expect the Panthers to win by about a touchdown. If you’re betting on Carolina, they’ll need to win by at least 5 points for your ticket to cash. On the flip side, Saints backers would need New Orleans to either win the game or keep the loss within 4 points. With new players on both rosters, the spread could look completely different by kickoff. Anything’s possible, and we’ll have a much better idea of how these two teams stack up once the season gets underway.
Panthers vs Saints Moneyline: What To Know
The Panthers sit at -198 on the moneyline, making them the favorites in their Week 10 matchup against the Saints. That means you’d have to risk more to get a solid payout. Meanwhile, the Saints are at +164, so a $100 bet on New Orleans would win you $164 if they pull off the upset. At those odds, the Saints have a 37.9% chance to win outright.
Panthers Chances To Win vs Saints
The Panthers’ roster looks much stronger this year, giving them an edge over their NFC South rivals. Carolina hosts the first game, and we expect them to walk away with a win. New Orleans faces an uphill battle with a new head coach and a rookie quarterback, and even with the game not coming until Week 10, that may not be enough time for the Saints to find their rhythm. Carolina sparked hope at the end of last season, and if they carry that momentum over with their improved roster, the Panthers will have no problem covering the spread.
How The Panthers Win vs Saints
Carolina can take down the Saints if the offensive line gives Bryce Young the time he needs to make plays and opens lanes for the running backs to gain yards. On defense, the Panthers are expected to be much improved from last season. If they can pressure New Orleans’ passing game, Carolina should have a well‑balanced team ready to take on the Saints
- 📈 Strength: The running back group, led by Chuba Hubbard, was solid last year. Adding Rico Dowdle and rookie Trevor Etienne makes the Panthers’ ground attack even stronger.
- 📉 Weakness: Turnovers. The Panthers were one of the worst in the NFL in the number of turnovers they had on offense.
How The Saints Win vs Panthers
The Saints have a new head coach and a new quarterback, so they are in a rebuild, and things don't look promising for the 2025 season. But if they can have a somewhat structured roster by the Week 10 matchup, the Saints could prey on Carolina's weaknesses and win the game. This is where the Saints' defense is going to be a factor.
- 📈 Strength: The powerful offensive line could allow for a dynamic run game.
- 📉 Weakness: The quarterback position. With no real leader on offense, the passing game could be troublesome for the Saints.
History of Panthers Saints Games
The Panthers and Saints have played 60 times in the regular season and once in the postseason. The Saints lead the series 32-29. Carolina is 14-17 on the road against New Orleans and 15-15 at home.
All-Time Best Panthers Saints Games
The Saints and Panthers have had some incredible matchups over the last few decades. Here are some of the most memorable contests:
Game 1: 1-7-2018 (2017 NFC Wild Card Round)
The Saints and Panthers met in the 2017 NFL Playoffs for the first time in NFL history. The Saints jumped out to a 21-9 lead going into halftime, and a few late scores by the Panthers allowed them to sneak back into the game. However, the Saints would win 31-26 and would advance to Round 2 of the NFL playoffs.
Game 2: 10-16-2016 (Week 6)
This was one of the highest-scoring games in the rivalry, with 79 total points scored. This was a fantastic matchup between Cam Newton and Drew Brees in their primes, with the Saints getting the 41-38 win. Drew Brees threw for 465 yards and four touchdowns, which was one of his best performances in the NFL.
Game: 10-26-2003 (Week 8)
The Panthers and Saints have not played many overtime games, but this was one to remember in 2003. The Saints scored 17 points in the second quarter to jump out to a 17-10 lead at halftime. But both teams only managed to score field goals in the second half, and it was a 31-yard field goal by John Casey of the Panthers that ultimately ended this game. The Panthers would get the win and advance to 6-1 on the season and would eventually make it to the Super Bowl, losing to the Patriots.
Other Matchups This Season
How Far Will The Panthers Go This Season?
Panthers Vs Saints FAQs
The Panthers play the Saints in Week 10 and Week 15 of the 2025 season. Carolina will host New Orleans in the first matchup on November 9 and travel to New Orleans for the Week 15 game on December 14.
Early odds have the Panthers as the favorites to win both games against the Saints. Since the 2025 season hasn’t started yet, these odds will most likely change before the games. Still, Carolina looks to have the early edge on paper.
Author
Brandon Justice is a Writer, Commercial Editor, and Fact Checker for BetCarolina.com. He's covered numerous sports betting perspectives for over six years, including everything from analysis & daily picks to reviews & guides. Additionally, he spent six seasons covering college football. The Carolina Panthers follow him on Twitter.
