Clemson Tigers vs. LSU Tigers: Betting Odds, Picks & Predictions
Key Takeaways:
- ⏰ When is Clemson vs LSU? 7:30 PM, August 30, 2025
- đź“ş How To Watch: ABC
- 🏟️ Where is the Clemson-LSU game? Memorial Stadium, Clemson, SC
It's a Top-10 matchup under the lights in Death Valley, as No. 9 LSU travels to No. 4 Clemson. Both Tigers enter the season ranked in the top‑20 and are led by Heisman-contending QBs.
Here’s my betting preview and complete breakdown of Clemson-LSU odds, kicking off the primetime college football season.
Clemson vs. LSU Odds: Who Is Favored To Win?
Clemson is favored by roughly a field goal at home. Most North Carolina sportsbooks list the Tigers from the ACC at ‑3.5 (-105) with a total of 57.5 points. LSU backers can get +3.5 at roughly ‑115 or a moneyline around +145.
| Team | No. 9 LSU | No. 4 Clemson |
|---|---|---|
| Spread | +3.5 (-115) | -3.5 (-105) |
| Total | O57.5 (-105) | U57.5 (-115) |
| Moneyline | +145 | -170 |
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What The Spread Tells Us
The modest spread suggests sportsbooks view this as a coin flip leaning toward Clemson’s home‑field advantage.
Clemson has won 31 of its last 33 non‑conference games at Memorial Stadium, yet they've have failed to cover the spread in each of their last four home games. LSU, meanwhile, has won eight of its last nine non‑conference games and covered six of its last eight games against top‑5 opponents.
Early lines opened around Clemson ‑2.5, but sharp money on the home side pushed the line up to ‑3.5/‑4. Clemson’s dominance at Memorial Stadium and LSU’s poor record in season openers (five straight losses ATS) were key factors.
What The Moneyline Tells Us
A Clemson moneyline of ‑170 implies about a 63% chance of winning, while LSU at +145 implies roughly a 41 % chance (the remainder is sportsbook vig).
Clemson’s strong home record and continuity at quarterback explain the shorter odds but a slight majority of early bettors appear to like LSU to cover the spread, reflecting confidence in LSU’s ability to compete on the road.
Chances Clemson Beats LSU
| Odds | Clemson | |
|---|---|---|
| Spread | -3.5 (-105) | 52% |
| Moneyline | -170 | 63% |
How Clemson Wins vs. LSU
To win, Clemson must capitalize on its balanced offense, pressure LSU’s Garrett Nussmeier, and avoid the slow starts that have plagued Dabo Swinney’s teams against SEC opponents (1‑6 ATS vs SEC).
- Strengths: Home dominance, efficient passing attack, stout defensive front.
- Weaknesses: Recent struggles to cover at home and vs SEC teams
Clemson returns quarterback Cade Klubnik, who threw 36 touchdown passes against only six interceptions last season and nearly 7,200 yards in his career. Returning WRs Antonio Williams (75 catches, 11 TDs) and deep‑threat TJ Moore behind an experienced offensive line should be the recipe for offensive fireworks, considering the big-play potential that freshman running back Gideon Davidson is bringing to Death Valley.
Defensively, Clemson features linebacker Sammy Brown (80 tackles, 5 sacks) and edge rusher TJ Parker (16.5 sacks over two seasons).
How LSU Wins vs. Clemson
For LSU to win, its offensive line must protect Nussmeier against Clemson’s pass rush, and the defense must slow Clemson’s passing game.
- Strengths: elite quarterback play, deep skill‑position talent, disruptive linebackers.
- Weaknesses: questions on the offensive line and a five‑game ATS losing streak in season openers
LSU QB Garrett Nussmeier can exploit Clemson’s secondary. Nussmeier threw for over 4,000 yards and 29 touchdowns with 12 interceptions last season and has completed 20+ passes in 14 straight games. The offense also returns running back Caden Durham, who rushed for 753 yards in 2024 and gained 753 yards in 2024. Receivers Aaron Anderson (61 catches, 884 yards, five TDs) and deep threat Nic Anderson (21 yards per catch) give Nussmeier explosive options.
LSU’s defense also features All‑SEC linebacker Whit Weeks (125 tackles and 3.5 sacks) and the return of edge rusher Harold Perkins Jr. from injury.
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Clemson-LSU Prop Bets
Prop betting lines for Clemson-LSU will move leading up to and throughout the game, so it is important to stay on top of what, when, and where odds are available. Here are some interesting props on FanDuel Sportsbook right now.
Clemson-LSU Player Props
Here are my favorite prop bets for Clemson vs. LSU.
- Cade Klubnik O/U 260.5 Passing Yards (-114)
- Garrett Nussmeier O/U 290.5 Passing Yards (-114)
- Caden Durham Anytime TD (-130)
- Antonio Williams Anytime TD (+100)
- Antonio Williams O/U 61.5 Receiving Yards (-114)
LSU-Clemson Picks & Prediction
Based on my hours of research and having paid attention to this game all summer, these are my expert betting picks for Clemson vs. LSU.
âś… Pick: Clemson -3.5
💡 Prediction: As I mentioned before Clemson struggles to get out of the gates against SEC opponents and if anybody knows that, its Dabo Sweeny. I don’t think Dabo lets a slow start derail a big opportunity like this in primetime. Clemson starts strong and never takes its foot off the gas, easily covering 3.5 and cashing the over: Clemson wins 42-28
History of Clemson vs. LSU
Although both programs proudly claim the “Death Valley” nickname, they have only met four times. LSU leads the series 3‑1.
The rivalry began in the 1959 Sugar Bowl, when top‑ranked LSU, featuring Heisman winner Billy Cannon, beat Clemson 7‑0. It resumed in the 1996 Peach Bowl (LSU 10, Clemson 7) and the 2012 Chick‑fil‑A Bowl, where Tajh Boyd threw for 346 yards and two touchdowns and wide receiver DeAndre Hopkins caught 191 yards in Clemson’s 25‑24 comeback win. The most recent meeting was the 2020 CFP National Championship, when Joe Burrow passed for 463 yards and five touchdowns, leading LSU to a 42‑25 win over Clemson. Every contest has been a major bowl or championship game, adding to the lore despite the limited number of meetings.
All-Time Best Clemson/LSU Games
Game 1 – 1959 Sugar Bowl (Jan. 1 1959, New Orleans) – No. 1 LSU and Clemson fought in a defensive battle decided by Billy Cannon’s third‑quarter touchdown. Clemson’s late fumble on the goal line preserved LSU’s 7‑0 win and delivered its first national title
Game 2 – 2012 Chick‑fil‑A Bowl (Dec. 31 2012, Atlanta) – Clemson quarterback Tajh Boyd threw for 346 yards and three touchdowns while absorbing heavy hits from LSU’s pass rush. Receiver DeAndre Hopkins added 191 yards and two scores. Boyd led an 87‑yard drive, converting two fourth downs before Chandler Catanzaro’s last‑second field goal secured Clemson’s 25‑24 comeback win.
Game 3 – 2020 CFP National Championship (Jan. 13 2020, New Orleans) – Undefeated Clemson built a 17‑7 lead, but LSU quarterback Joe Burrow produced one of the greatest championship performances ever with 463 passing yards, five passing touchdowns and a rushing score. LSU’s 42‑25 victory capped a 15‑0 season and ended Clemson’s 29‑game winning streak.
Clemson vs. LSU Odds FAQ
Clemson is favored by 3.5 points; a ‑3.5 (-105) spread means Clemson must win by at least four points to cover. Conversely, LSU covers if it loses by four points or less, or wins outright. You can also take either team to win straight up.
Choose a licensed sportsbook, deposit funds, navigate to the college football section, find Clemson vs LSU, and select a bet type (spread, moneyline, total, props, etc.). Confirm your wager and amount.
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